John O'Shea is out of Ireland's team to face South Africa in a friendly in Limerick this evening.
The defender has returned to Manchester United to have scans on a calf problem.
Ireland boss Giovanni Trapattoni said the 28-year-old had been sent back to his club in an effort to prevent the damage from getting any worse.
O'Shea joins Shay Given, Richard Dunne, Robbie Keane, Kevin Kilbane and Stephen Hunt in the list of absentees for the match at Thomond Park in Limerick.
Manager Trapattoni had allowed Given, Dunne, Keane and Kilbane to return to their clubs.
Hunt misses the friendly at Thomond Park because of personal reasons.
Celtic defender Darren O'Dea, who is currently on loan at Reading, has been called up to the squad.